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Scientists report that early clinical research on Retatrutide revealed up to 82% reductions in liver fat. This experimental dr*g, part of a new class of multiagonist therapies, targets metabolic pathways to improve As the role of #GLP1 therapies in #MASLD continues to grow, clinicians need clear guidance. A new Practice Guidance update in #HEPATOLOGY provides evidence based recommendations on using semaglutide therapy for MASH, including Understanding Semaglutide Weight Loss Dosage: Key Information GLP1 causing depression? : r glp1
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.6 ★★★★★
Based on 2052 reviews
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Product Reviews
★★★★★ 5
MUST BUY
This was a nice addition to my Prequel collection! I just loved this product and so did my skin. This is a very light weight product that hydrates and plumps the skin. I apply it after my VitC serum and it works great under my makeup. I will be repurchasing. Such a good product at a good price!
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Reviewed in the United States on April 14, 2026
★★★★★ 5
Makes my skin feel firmer
I bought this and the Prequel SPF, my first time using this product line. Definitely impressed and in my opinion, a great price for what seems like a quality product. The serum has a lightweight texture,, absorbs quickly, and my skin looks and feels well hydrated right away. More so than when I use a regular hyaluronic acid. There is no pilling or heavy feel so easy to use with other products. I can't say whether it improves skin texture over time or what the benefits are with continued use. I've been using it consistently with the SPF for the last two weeks, so it only been a short while. But when I put it on, my skin noticeably looks more springy and feels better throughout the day. I have mature, dry skin so I do use a moisturizer over this before sun protection. I imagine that if you have oily or normal skin you might be able to use this in place of moisturizer during the day.
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Reviewed in the United States on October 27, 2025
★★★★★ 5
Plump, Soft Skin with a Smooth Finish
I’ve really been enjoying the Prequel Skin Multi‑Quench Plumping Hydration Serum. It gives my skin a soft, hydrated feel without any heaviness, and it absorbs quickly so it never interferes with the rest of my routine. One of the best parts is how smoothly my makeup applies afterward—everything blends better and looks more even. Overall, it’s a lightweight, effective serum that adds the perfect boost of hydration.
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Reviewed in the United States on December 23, 2025
★★★★★ 5
New favorite moisture serum
I am blown away by this formula - it goes on silky and absorbs into the skin, giving it a plump, hydrated glow without ANY stickiness or annoying shine. Two pumps after cleansing and toner is just right but you can also go in heavier and use in place of a moisturizer. This truly gives me lasting moisture, which is amazing for a light to mid-weight serum. Wears great with other complexion products and under makeup. The glass bottle is luxe and the pump isn't the least bit messy. Glycerin is all the rage in terms of "hot" ingredients right now - and I have to say after using this, I'm a believer. I've pretty much replaced a classic daily moisturizer with pairing this serum before Strata Lipid Gold (another holy grail) - which works great under my moisturizing Japanese sunscreen (Canmake Mermaid Skin). These steps provide a flawless, juicy base under makeup for my maturing (43-year old) skin. Can't wait to try more products in this line.
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Reviewed in the United States on September 29, 2024
★★★★★ 4
Good
Moisturizing and gel like. It pills when used with the Prequel mineral SPF.
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Reviewed in the United States on March 31, 2026
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